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KMID : 1103720100630030287
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Journal of the Korean Society of Radiology
2010 Volume.63 No. 3 p.287 ~ p.292
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Factors Affecting 18F-Fluorodeoxyglucose (FDG) Uptake in Breast Cancer
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Jeong Sun-Hye
Lee Eun-Hae
Bark Jung-Mi
Lee Hye-Kyung
Yi Boem-Ha
Choi Na-Mi
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Abstract
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Objective:To evaluate factors affecting 18F-Fluorodeoxyglucose (FDG) uptake in breast cancer.
Methods: For 3 years from 2006, 180 patients (mean age 48-years-old) with 187 breast cancers underwent positron emission tomography-computed tomography (PET/CT; biograph2, Siemens) at our institute and were enrolled in this study. We evaluated whether there was a correlation between the peak standardized uptake value (pSUV) of PET/CT and the histologic type of the breast cancers (n=187), grade of the invasive ductal cancers (n=142), and tumor size (n=153).
Results: The different histologic types of breast cancers include IDCs (n=156), in situ ductal carcinoma (n=10), papillary cancer (n=6), mucinous cancer (n=6), invasive lobular cancer (n=4), medullary cancer (n=3), metaplastic cancer (n=1), and neuroendocrine cancer (n=1). pSUV showed significant differences according to histologic type (p<0.005). For the available cases (n=142), IDCs were classified as grade 1 (n=25), grade 2 (n=66), and grade 3 (n=51) and correlated with the histologic grade of IDCs (rho=0.41, p<0.001). pSUV was correlated with tumor size regardless of histologic type (rho=0.525, p<0.001). In low grade IDCs, pSUV was correlated with tumor size (rho=0.48-0.86, p<0.001), but not in high grade IDCs (p>0.001).
Conclusions:Regardless of histologic type, the larger the breast cancer, the higher the pSUV; in addition, the higher the grade of IDCs, the higher the pSUV. For the low grade IDCs, pSUV is correlated with tumor size; however, this is not the case in high grade IDCs.
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KEYWORD
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Breast Neoplasms , Positron-Emission Tomography, Fluorodeoxyglucose F18
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